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NeuN (RBFOX3) Rabbit Polyclonal Antibody
CAT＃: TA323300S
Anti-RBFOX3 Rabbit Polyclonal Antibody
Size: 100 ul
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CNY 800.00
CNY 1,280.00
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CNY 300.00
CNY 1,430.00
CNY 3,080.00
Specifications
| Product Data | |
| Applications | IHC, WB |
| Recommend Dilution | WB: 500-2000 WB positive control: Mouse brain tissue lysate IHC: 50-200 Positive control: Human thyroid cancer Predicted cell location: Cytoplasm and Nucleus |
| Reactivity | Human, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Immunogen | Synthetic peptide corresponding to a region derived from 88-102 amino acids of RNA binding protein, fox-1 homolog (C. elegans) 3 |
| Formulation | PBS pH7.3, 0.05% NaN3, 50% glycerol |
| Purification | Antigen affinity purification |
| Conjugation | Unconjugated |
| Storage Condition | Store at -20°C as received. |
| Predicted Protein Size | 34 kDa |
| Gene Name | RNA binding protein, fox-1 homolog 3 |
| Database Link | |
| Background | Immunoprecipitation and mass spectrometry of the two major NeuN species at 45–50 kDa identified both as the RNA binding protein Rbfox3 (a member of the Fox family of alternative splicing factors); confirming and extending the identification of the 45 kDa band as Rbfox3. Mapping of the anti-NeuN reactive epitopes in both R3hdm2 and Rbfox3 reveals a common proline- and glutamine-rich domain that lies at the N-terminus of the Rbfox3 protein. Nuclear Rbfox3 isoforms can also enhance the inclusion of cryptic exons in the Rbfox2 mRNA; resulting in nonsense-mediated decay of the message; thereby contributing to the negative regulation of Rbfox2 by Rbfox3 through a novel mechanism. |
| Synonyms | FOX-3; FOX3; HRNBP3; NEUN |
| Reference Data | |
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NeuN Rabbit Polyclonal Antibody
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