ABHD12 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC
Recommend Dilution	IHC: 25-100 Positive control: Human thyroid cancer Predicted cell location: Cytoplasm
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Fusion protein corresponding to a region derived from 96-398 amino acids of human abhydrolase domain containing 12
Formulation	PBS pH7.3, 0.05% NaN3, 50% glycerol
Concentration	lot specific
Purification	Antigen affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	abhydrolase domain containing 12
Database Link	NP_056415 Entrez Gene 76192 MouseEntrez Gene 499913 RatEntrez Gene 26090 Human UniProt ID Q8N2K0
Background	This gene encodes an enzyme that catalyzes the hydrolysis of 2-arachidonoyl glycerol (2-AG); the main endocannabinoid lipid transmitter that acts on cannabinoid receptors; CB1 and CB2. The endocannabinoid system is involved in a wide range of physiological processes; including neurotransmission; mood; appetite; pain appreciation; addiction behavior; and inflammation. Mutations in this gene are associated with the neurodegenerative disease; PHARC (polyneuropathy; hearing loss; ataxia; retinitis pigmentosa; and cataract); resulting from an inborn error of endocannabinoid metabolism. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.
Synonyms	ABHD12A; BEM46L2; C20orf22; dJ965G21.2; PHARC
Reference Data
Protein Families	Protease, Transmembrane

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