CDK9 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	WB: 500-2000 WB positive control: 823 and Hela cells
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Fusion protein corresponding to a region derived from 19-315 amino acids of human cyclin-dependent kinase 9
Formulation	PBS pH7.3, 0.05% NaN3, 50% glycerol
Concentration	lot specific
Purification	Antigen affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	53 kDa
Gene Name	cyclin-dependent kinase 9
Database Link	NP_001252 Entrez Gene 107951 MouseEntrez Gene 362110 RatEntrez Gene 1025 Human UniProt ID P50750
Background	The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of S. cerevisiae cdc28; and S. pombe cdc2; and known as important cell cycle regulators. This kinase was found to be a component of the multiprotein complex TAK/P-TEFb; which is an elongation factor for RNA polymerase II-directed transcription and functions by phosphorylating the C-terminal domain of the largest subunit of RNA polymerase II. This protein forms a complex with and is regulated by its regulatory subunit cyclin T or cyclin K. HIV-1 Tat protein was found to interact with this protein and cyclin T; which suggested a possible involvement of this protein in AIDS.
Synonyms	C-2k; CDC2L4; CTK1; PITALRE; TAK
Reference Data
Protein Families	Druggable Genome, Protein Kinase, Transcription Factors

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