DDB1 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC, WB
Recommend Dilution	WB: 200-1000 WB positive control: MCF-7, Hela and HepG2 cells IHC: 10-100 Positive control: Human cervical cancer Predicted cell location: Cytoplasm, Nucleus
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic peptide corresponding to a region derived from 1125-1140 amino acids of Human DNA damage-binding protein 1
Formulation	PBS pH7.3, 0.05% NaN3, 50% glycerol
Concentration	lot specific
Purification	Antigen affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	127 kDa
Gene Name	damage specific DNA binding protein 1
Database Link	NP_001914 Entrez Gene 13194 MouseEntrez Gene 64470 RatEntrez Gene 1642 Human UniProt ID Q16531
Background	The protein encoded by this gene is the large subunit (p127) of the heterodimeric DNA damage-binding (DDB) complex while another protein (p48) forms the small subunit. This protein complex functions in nucleotide-excision repair and binds to DNA following UV damage. Defective activity of this complex causes the repair defect in patients with xeroderma pigmentosum complementation group E (XPE) - an autosomal recessive disorder characterized by photosensitivity and early onset of carcinomas. However; it remains for mutation analysis to demonstrate whether the defect in XPE patients is in this gene or the gene encoding the small subunit. In addition; Best vitelliform mascular dystrophy is mapped to the same region as this gene on 11q; but no sequence alternations of this gene are demonstrated in Best disease patients. The protein encoded by this gene also functions as an adaptor molecule for the cullin 4 (CUL4) ubiquitin E3 ligase complex by facilitating the binding of substrates to this complex and the ubiquitination of proteins.
Synonyms	DDBA; UV-DDB1; XAP1; XPCE; XPE; XPE-BF
Reference Data
Protein Families	Druggable Genome
Protein Pathways	Nucleotide excision repair, Ubiquitin mediated proteolysis

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