p95 NBS1 (NBN) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC
Recommend Dilution	IHC: 25-100 Positive control: Human breast cancer Predicted cell location: Cytoplasm
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic peptide corresponding to a region derived from 729-743 amino acids of human nibrin
Formulation	PBS pH7.3, 0.05% NaN3, 50% glycerol
Concentration	lot specific
Purification	Antigen affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	nibrin
Database Link	NP_002476 Entrez Gene 27354 MouseEntrez Gene 85482 RatEntrez Gene 4683 Human UniProt ID O60934
Background	Mutations in this gene are associated with Nijmegen breakage syndrome; an autosomal recessive chromosomal instability syndrome characterized by microcephaly; growth retardation; immunodeficiency; and cancer predisposition. The encoded protein is a member of the MRE11/RAD50 double-strand break repair complex which consists of 5 proteins. This gene product is thought to be involved in DNA double-strand break repair and DNA damage-induced checkpoint activation.
Synonyms	AT-V1; AT-V2; ATV; NBS; NBS1; P95
Reference Data
Protein Families	Druggable Genome
Protein Pathways	Homologous recombination

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