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RPTP mu (PTPRM) Rabbit Polyclonal Antibody
CAT＃: TA322946S
Anti-PTPRM Rabbit Polyclonal Antibody
Size: 100 ul
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CNY 800.00
CNY 1,280.00
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CNY 300.00
CNY 1,430.00
CNY 4,840.00
Specifications
| Product Data | |
| Applications | IHC |
| Recommend Dilution | IHC: 50-200 Positive control: Human breast cancer Predicted cell location: Cytoplasm |
| Reactivity | Human, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Immunogen | Synthetic peptide corresponding to a region derived from 1370-1385 amino acids of Human protein tyrosine phosphatase, receptor type, M |
| Formulation | PBS pH7.3, 0.05% NaN3, 50% glycerol |
| Purification | Antigen affinity purification |
| Conjugation | Unconjugated |
| Storage Condition | Store at -20°C as received. |
| Gene Name | protein tyrosine phosphatase, receptor type M |
| Database Link | |
| Background | The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth; differentiation; mitotic cycle; and oncogenic transformation. This PTP possesses an extracellular region; a single transmembrane region; and two tandem catalytic domains; and thus represents a receptor-type PTP. The extracellular region contains a meprin-A5 antigen-PTP mu (MAM) domain; an Ig-like domain and four fibronectin type III-like repeats. This PTP has been shown to mediate cell-cell aggregation through the interaction with another molecule of this PTP on an adjacent cell. This PTP can interact with scaffolding protein RACK1/GNB2L1; which may be necessary for the downstream signaling in response to cell-cell adhesion. Alternative splicing results in multiple transcripts encoding distinct isoforms. |
| Synonyms | hR-PTPu; PTPRL1; R-PTP-MU; RPTPM; RPTPU |
| Reference Data | |
| Protein Families | Druggable Genome, Phosphatase, Transmembrane |
| Protein Pathways | Adherens junction, Cell adhesion molecules (CAMs) |
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