SNAP25 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC, WB
Recommend Dilution	WB: 500-2000 WB positive control: Hela cells IHC: 25-100 Positive control: Human brain Predicted cell location: Cytoplasm
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Full length fusion protein
Formulation	PBS pH7.3, 0.05% NaN3, 50% glycerol
Concentration	lot specific
Purification	Antigen affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	23 kDa
Gene Name	synaptosome associated protein 25kDa
Database Link	NP_003072 Entrez Gene 20614 MouseEntrez Gene 25012 RatEntrez Gene 6616 Human UniProt ID P60880
Background	Synaptic vesicle membrane docking and fusion is mediated by SNAREs (soluble N-ethylmaleimide-sensitive factor attachment protein receptors) located on the vesicle membrane (v-SNAREs) and the target membrane (t-SNAREs). The assembled v-SNARE/t-SNARE complex consists of a bundle of four helices; one of which is supplied by v-SNARE and the other three by t-SNARE. For t-SNAREs on the plasma membrane; the protein syntaxin supplies one helix and the protein encoded by this gene contributes the other two. Therefore; this gene product is a presynaptic plasma membrane protein involved in the regulation of neurotransmitter release. Two alternative transcript variants encoding different protein isoforms have been described for this gene.?
Synonyms	bA416N4.2; dJ1068F16.2; RIC-4; RIC4; SEC9; SNAP; SNAP-25
Reference Data
Protein Families	Druggable Genome
Protein Pathways	SNARE interactions in vesicular transport

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