LRP2 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC
Recommend Dilution	IHC: 50-200 Positive control: Human esophagus cancer Predicted cell location: Cell membrane, Cytoplasm
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic peptide corresponding to a region derived from 4640-4054 amino acids of Human low density lipoprotein receptor-related protein 2
Formulation	PBS pH7.3, 0.05% NaN3, 50% glycerol
Concentration	lot specific
Purification	Antigen affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	LDL receptor related protein 2
Database Link	NP_004516 Entrez Gene 14725 MouseEntrez Gene 29216 RatEntrez Gene 4036 Human UniProt ID P98164
Background	The protein encoded by this gene; low density lipoprotein-related protein 2 (LRP2) or megalin; is a multi-ligand endocytic receptor that is expressed in many different tissues but primarily in absorptive epithilial tissues such as the kidney. This glycoprotein has a large amino-terminal extracellular domain; a single transmembrane domain; and a short carboxy-terminal cytoplasmic tail. The extracellular ligand-binding-domains bind diverse macromolecules including albumin; apolipoproteins B and E; and lipoprotein lipase. The LRP2 protein is critical for the reuptake of numerous ligands; including lipoproteins; sterols; vitamin-binding proteins; and hormones. This protein also has a role in cell-signaling; extracellular ligands include parathyroid horomones and the morphogen sonic hedgehog while cytosolic ligands include MAP kinase scaffold proteins and JNK interacting proteins. Recycling of this membrane receptor is regulated by phosphorylation of its cytoplasmic domain. Mutations in this gene cause Donnai-Barrow syndrome (DBS) and facio-oculoacoustico-renal syndrome (FOAR).
Synonyms	DBS; GP330
Reference Data
Protein Families	Druggable Genome, Transmembrane
Protein Pathways	Hedgehog signaling pathway

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