HDAC1 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC, WB
Recommend Dilution	WB: 500-2000 WB positive control: Human colon and kidney cancer tissue IHC: 25-100 Positive control: Human tonsil Predicted cell location: Cytoplasm, Nucleus
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic peptide corresponding to a region derived from 469-482 amino acids of Human histone deacetylase 1
Formulation	PBS pH7.3, 0.05% NaN3, 50% glycerol
Concentration	lot specific
Purification	Antigen affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	55 kDa
Gene Name	histone deacetylase 1
Database Link	NP_004955 Entrez Gene 297893 RatEntrez Gene 433759 MouseEntrez Gene 3065 Human UniProt ID Q13547
Background	Histone acetylation and deacetylation; catalyzed by multisubunit complexes; play a key role in the regulation of eukaryotic gene expression. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family and is a component of the histone deacetylase complex. It also interacts with retinoblastoma tumor-suppressor protein and this complex is a key element in the control of cell proliferation and differentiation. Together with metastasis-associated protein-2; it deacetylates p53 and modulates its effect on cell growth and apoptosis.
Synonyms	GON-10; HD1; RPD3; RPD3L1
Reference Data
Protein Families	Adult stem cells, Druggable Genome, Stem cell - Pluripotency, Stem cell relevant signaling - DSL/Notch pathway, Transcription Factors
Protein Pathways	Cell cycle, Chronic myeloid leukemia, Huntington's disease, Notch signaling pathway, Pathways in cancer

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