MADH7 (SMAD7) Rabbit Polyclonal Antibody
CAT#: TA322546
Anti-SMAD7 rabbit polyclonal antibody
Size: 25 ul
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CNY 1,999.00
CNY 3,280.00
Cited in 1 publication. |
CNY 300.00
CNY 1,430.00
Specifications
Product Data | |
Applications | IHC, WB |
Recommend Dilution | WB: 500-2000 WB positive control: Mouse heart tissue lysate IHC: 40-200 Positive control: Human esophagus cancer Predicted cell location: Nucleus and Cytoplasm |
Reactivity | Human, Mouse, Rat |
Host | Rabbit |
Clonality | Polyclonal |
Immunogen | Synthetic peptide corresponding to a region derived from 370-383 amino acids of Human SMAD family member 7 |
Formulation | PBS pH7.3, 0.05% NaN3, 50% glycerol |
Concentration | lot specific |
Purification | Antigen affinity purification |
Conjugation | Unconjugated |
Storage Condition | Store at -20°C as received. |
Predicted Protein Size | 46 kDa |
Gene Name | SMAD family member 7 |
Database Link | |
Background | The protein encoded by this gene is a nuclear protein that binds the E3 ubiquitin ligase SMURF2. Upon binding, this complex translocates to the cytoplasm, where it interacts with TGF-beta receptor type-1 (TGFBR1), leading to the degradation of both the encoded protein and TGFBR1. Expression of this gene is induced by TGFBR1. Variations in this gene are a cause of susceptibility to colorectal cancer type 3 (CRCS3). Several transcript variants encoding different isoforms have been found for this gene. |
Synonyms | CRCS3; MADH7; MADH8 |
Reference Data | |
Protein Families | Druggable Genome, Transcription Factors |
Protein Pathways | TGF-beta signaling pathway |
Citations (1)
The use of this Antibodies has been cited in the following citations: |
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The Modulatory Properties of Chronic Antidepressant Drugs Treatment on the Brain Chemokine - Chemokine Receptor Network: A Molecular Study in an Animal Model of Depression
,Trojan, E;Ślusarczyk, J;Chamera, K;Kotarska, K;Głombik, K;Kubera, M;Basta-Kaim, A;,
Front Pharmacol
,PubMed ID 29163165
[SMAD7]
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