PDCD10 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC, WB
Recommend Dilution	WB: 200-1000 WB positive control: Hela cells, human fetal brain tissue and K562 cells IHC: 15-50 Positive control: Human renal cancer Predicted cell location: Cytoplasm
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Full length fusion protein
Formulation	PBS pH7.3, 0.05% NaN3, 50% glycerol
Purification	Antigen affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	25 kDa
Gene Name	programmed cell death 10
Database Link	NP_009148 Entrez Gene 56426 MouseEntrez Gene 494345 RatEntrez Gene 11235 Human UniProt ID Q9BUL8
Background	This gene encodes an evolutionarily conserved protein associated with cell apoptosis. The protein interacts with the serine/threonine protein kinase MST4 to modulate the extracellular signal-regulated kinase (ERK) pathway. It also interacts with and is phosphoryated by serine/threonine kinase 25; and is thought to function in a signaling pathway essential for vascular developent. Mutations in this gene are one cause of cerebral cavernous malformations; which are vascular malformations that cause seizures and cerebral hemorrhages. Multiple alternatively spliced variants; encoding the same protein; have been identified.
Synonyms	CCM3; TFAR15
Reference Data
Protein Families	Druggable Genome

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