NTAL (LAT2) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC
Recommend Dilution	IHC: 10-50 Positive control: Human colon cancer Predicted cell location: Cytoplasm
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	Fusion protein corresponding to a region derived from 27-243 amino acids of human linker for activation of T cells family, member 2
Formulation	PBS pH7.3, 0.05% NaN3, 50% glycerol
Concentration	lot specific
Purification	Antigen affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	linker for activation of T-cells family member 2
Database Link	NP_054865 Entrez Gene 7462 Human UniProt ID Q9GZY6
Background	This gene is one of the contiguous genes at 7q11.23 commonly deleted in Williams syndrome; a multisystem developmental disorder. This gene consists of at least 14 exons; and its alternative splicing generates 3 transcript variants; all encoding the same protein. Involved in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. May also be involved in BCR (B-cell antigen receptor)-mediated signaling in B-cells and FCGR1 (high affinity immunoglobulin gamma Fc receptor I)-mediated signaling in myeloid cells. Couples activation of these receptors and their associated kinases with distal intracellular events through the recruitment of GRB2.
Synonyms	HSPC046; LAB; NTAL; WBSCR5; WBSCR15; WSCR5
Reference Data
Protein Families	Transmembrane

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