CBX8 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC, WB
Recommend Dilution	WB: 500-2000 WB positive control: 231 and 293T cell lysates IHC: 50-100 Positive control: Human liver cancer Predicted cell location: Nucleus and Cytoplasm
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	Fusion protein corresponding to a C terminal 300 amino acids of human chromobox homolog 8
Formulation	PBS pH7.3, 0.05% NaN3, 50% glycerol
Concentration	lot specific
Purification	Antigen affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	43 kDa
Gene Name	chromobox 8
Database Link	NP_065700 Entrez Gene 57332 Human UniProt ID Q9HC52
Background	Chromobox protein homolog 8 is a protein that in humans is encoded by the CBX8 gene.CBX8 has been shown to interact with RING1 and MLLT1.Component of a Polycomb group (PcG) multiprotein PRC1-like complex; a complex class required to maintain the transcriptionally repressive state of many genes; including Hox genes; throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119'; rendering chromatin heritably changed in its expressibility.
Synonyms	PC3; RC1
Reference Data
Protein Families	Transcription Factors

*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.