MMP25 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC, WB
Recommend Dilution	WB: 500-2000 WB positive control: 823 cells IHC: 50-200 Positive control: Human lung cancer Predicted cell location: Cytoplasm
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic peptide corresponding to a region derived from 126-139 amino acids of human matrix metallopeptidase 25
Formulation	PBS pH7.3, 0.05% NaN3, 50% glycerol
Purification	Antigen affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	63 kDa
Gene Name	matrix metallopeptidase 25
Database Link	NP_071913 Entrez Gene 64386 Human UniProt ID Q9NPA2
Background	Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes; such as embryonic development; reproduction; and tissue remodeling; as well as in disease processes; such as arthritis and metastasis. Most MMPs are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However; the protein encoded by this gene is a member of the membrane-type MMP (MT-MMP) subfamily; attached to the plasma membrane via a glycosylphosphatidyl inositol anchor. In response to bacterial infection or inflammation; the encoded protein is thought to inactivate alpha-1 proteinase inhibitor; a major tissue protectant against proteolytic enzymes released by activated neutrophils; facilitating the transendothelial migration of neutrophils to inflammatory sites. The encoded protein may also play a role in tumor invasion and metastasis through activation of MMP2. The gene has previously been referred to as MMP20 but has been renamed MMP25.
Synonyms	MMP-25; MMP20; MMP20A; MMPL1; MT-MMP 6; MT-MMP6; MT6-MMP; MT6MMP; MTMMP6
Reference Data
Protein Families	Druggable Genome

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