Tropomyosin 2 (TPM2) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC, WB
Recommend Dilution	WB: 500-2000 WB positive control: Human cervical cancer tissue IHC: 50-200 Positive control: Human esophagus cancer Predicted cell location: Cytoplasm
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic peptide corresponding to a region derived from 188-207 amino acids of Human tropomyosin 2 (beta)
Formulation	PBS pH7.3, 0.05% NaN3, 50% glycerol
Concentration	lot specific
Purification	Antigen affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	33 kDa
Gene Name	tropomyosin 2 (beta)
Database Link	NP_998839 Entrez Gene 7169 Human UniProt ID P07951
Background	This gene encodes beta-tropomyosin; a member of the actin filament binding protein family; and mainly expressed in slow; type 1 muscle fibers. Mutations in this gene can alter the expression of other sarcomeric tropomyosin proteins; and cause cap disease; nemaline myopathy and distal arthrogryposis syndromes. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. TPM2 has been shown to interact with RRAD; PDLIM7 and TPM1.
Synonyms	AMCD1; DA1; DA2B; HEL-S-273; NEM4; TMSB
Reference Data
Protein Pathways	Cardiac muscle contraction, Dilated cardiomyopathy, Hypertrophic cardiomyopathy (HCM)

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