RHOC Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	WB: 500-2000 WB positive control: Human fetal brain tissue
Reactivity	Human, Mouse
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic peptide corresponding to a region derived from 179-189 amino acids of Human ras homolog family member C
Formulation	PBS pH7.3, 0.05% NaN3, 50% glycerol
Concentration	lot specific
Purification	Antigen affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	22 kDa
Gene Name	ras homolog family member C
Database Link	NP_786886 Entrez Gene 11853 MouseEntrez Gene 389 Human UniProt ID P08134
Background	This gene encodes a member of the Rho family of small GTPases; which cycle between inactive GDP-bound and active GTP-bound states and function as molecular switches in signal transduction cascades. Rho proteins promote reorganization of the actin cytoskeleton and regulate cell shape; attachment; and motility. The protein encoded by this gene is prenylated at its C-terminus; and localizes to the cytoplasm and plasma membrane. It is thought to be important in cell locomotion. Overexpression of this gene is associated with tumor cell proliferation and metastasis. Multiple alternatively spliced variants; encoding the same protein; have been identified.
Synonyms	ARH9; ARHC; H9; RHOH9
Reference Data
Protein Families	Druggable Genome

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