TRAF2 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC, WB
Recommend Dilution	WB: 200-1000 WB positive control: Human normal liver tissue IHC: 25-100 Positive control: Human lung cancer Predicted cell location: Cytoplasm
Reactivity	Human, Mouse
Host	Rabbit
Clonality	Polyclonal
Immunogen	Fusion protein corresponding to a region derived from 351-496 amino acids of human TNF receptor-associated factor 2
Formulation	PBS pH7.3, 0.05% NaN3, 50% glycerol
Concentration	lot specific
Purification	Antigen affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	TNF receptor associated factor 2
Database Link	NP_066961 Entrez Gene 22030 MouseEntrez Gene 7186 Human UniProt ID Q12933
Background	The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins associate with; and mediate the signal transduction from members of the TNF receptor superfamily. This protein directly interacts with TNF receptors; and forms a heterodimeric complex with TRAF1. This protein is required for TNF-alpha-mediated activation of MAPK8/JNK and NF-kappaB. The protein complex formed by this protein and TRAF1 interacts with the inhibitor-of-apoptosis proteins (IAPs); and functions as a mediator of the anti-apoptotic signals from TNF receptors. The interaction of this protein with TRADD; a TNF receptor associated apoptotic signal transducer; ensures the recruitment of IAPs for the direct inhibition of caspase activation. BIRC2/c-IAP1; an apoptosis inhibitor possessing ubiquitin ligase activity; can unbiquitinate and induce the degradation of this protein; and thus potentiate TNF-induced apoptosis. Multiple alternatively spliced transcript variants have been found for this gene; but the biological validity of only one transcript has been determined.
Synonyms	MGC:45012; TRAP; TRAP3
Reference Data
Protein Families	Druggable Genome
Protein Pathways	Adipocytokine signaling pathway, Apoptosis, MAPK signaling pathway, Pathways in cancer, RIG-I-like receptor signaling pathway, Small cell lung cancer

*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.