GJB6 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC, WB
Recommend Dilution	ELISA: 1:1000-5000, WB: 1:1000-5000, IHC: 1:50-200
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic peptide corresponding to a region derived from 230-245 amino acids of Human Gap junction beta-6 protein
Formulation	PBS pH7.3, 0.05% NaN3, 50% glycerol
Concentration	lot specific
Purification	Antigen affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	30 kDa
Gene Name	gap junction protein beta 6
Database Link	NP_006774 Entrez Gene 14623 MouseEntrez Gene 84403 RatEntrez Gene 10804 Human UniProt ID O95452
Background	Gap junctions allow the transport of ions and metabolites between the cytoplasm of adjacent cells. They are formed by two hemichannels; made up of six connexin proteins assembled in groups. Each connexin protein has four transmembrane segments; two extracellular loops; a cytoplasmic loop formed between the two inner transmembrane segments; and the N- and C-terminus both being in the cytoplasm. The specificity of the gap junction is determined by which connexin proteins comprise the hemichannel. In the past; connexin protein names were based on their molecular weight; however the new nomenclature uses sequential numbers based on which form (alpha or beta) of the gap junction is present. This gene encodes one of the connexin proteins. Mutations in this gene have been found in some forms of deafness and in some families with hidrotic ectodermal dysplasia.
Synonyms	CX30; DFNA3; DFNA3B; DFNB1B; ECTD2; ED2; EDH; HED; HED2
Reference Data
Protein Families	Druggable Genome, Transmembrane

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