PTP epsilon (PTPRE) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC
Recommend Dilution	IHC: 15-50 Positive control: Human breast cancer Predicted cell location: Cytoplasm
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Fusion protein corresponding to a region derived from 426-689 amino acids of human protein tyrosine phosphatase, receptor type, E
Formulation	PBS pH7.3, 0.05% NaN3, 50% glycerol
Concentration	lot specific
Purification	Antigen affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	protein tyrosine phosphatase, receptor type E
Database Link	NP_006495 Entrez Gene 19267 MouseEntrez Gene 114767 RatEntrez Gene 5791 Human UniProt ID P23469
Background	The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth; differentiation; mitotic cycle; and oncogenic transformation. Two alternatively spliced transcript variants of this gene have been reported; one of which encodes a receptor-type PTP that possesses a short extracellular domain; a single transmembrane region; and two tandem intracytoplasmic catalytic domains; Another one encodes a PTP that contains a distinct hydrophilic N-terminus; and thus represents a nonreceptor-type isoform of this PTP. Studies of the similar gene in mice suggested the regulatory roles of this PTP in RAS related signal transduction pathways; cytokines induced SATA signaling; as well as the activation of voltage-gated K+ channels.
Synonyms	HPTPE; PTPE; R-PTP-EPSILON
Reference Data
Protein Families	Druggable Genome, Phosphatase, Transmembrane

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