Calreticulin (CALR) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC, WB
Recommend Dilution	WB: 1000-5000 WB positive control: NIH/3T3 cells IHC: 50-200 Positive control: Human gasrtic cancer Predicted cell location: Cytoplasm
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Fusion protein corresponding to a region derived from 20-218 amino acids of human calreticulin
Formulation	PBS pH7.3, 0.05% NaN3, 50% glycerol
Concentration	lot specific
Purification	Antigen affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	48 kDa
Gene Name	calreticulin
Database Link	NP_004334 Entrez Gene 12317 MouseEntrez Gene 64202 RatEntrez Gene 811 Human UniProt ID P27797
Background	Calreticulin is a multifunctional protein that acts as a major Ca(2+)-binding (storage) protein in the lumen of the endoplasmic reticulum. It is also found in the nucleus; suggesting that it may have a role in transcription regulation. Calreticulin binds to the synthetic peptide KLGFFKR; which is almost identical to an amino acid sequence in the DNA-binding domain of the superfamily of nuclear receptors. Calreticulin binds to antibodies in certain sera of systemic lupus and Sjogren patients which contain anti-Ro/SSA antibodies; it is highly conserved among species; and it is located in the endoplasmic and sarcoplasmic reticulum where it may bind calcium. The amino terminus of calreticulin interacts with the DNA-binding domain of the glucocorticoid receptor and prevents the receptor from binding to its specific glucocorticoid response element.
Synonyms	cC1qR; CRT; HEL-S-99n; RO; SSA
Reference Data
Protein Families	Druggable Genome, Secreted Protein, Transcription Factors
Protein Pathways	Antigen processing and presentation

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