Tryptophan Hydroxylase (TPH1) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC
Recommend Dilution	IHC: 15-50 Positive control: Human thyroid cancer Predicted cell location: Cytoplasm
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Fusion protein corresponding to a region derived from C terminal 250 amino acids of human tryptophan hydroxylase 1
Formulation	PBS pH7.3, 0.05% NaN3, 50% glycerol
Concentration	lot specific
Purification	Antigen affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	tryptophan hydroxylase 1
Database Link	NP_004170 Entrez Gene 21990 MouseEntrez Gene 24848 RatEntrez Gene 7166 Human UniProt ID P17752
Background	This gene encodes a member of the aromatic amino acid hydroxylase family. The encoded protein catalyzes the first and rate limiting step in the biosynthesis of serotonin; an important hormone and neurotransmitter. Mutations in this gene have been associated with an elevated risk for a variety of diseases and disorders; including schizophrenia; somatic anxiety; anger-related traits; bipolar disorder; suicidal behavior; addictions; and others.
Synonyms	TPRH; TRPH
Reference Data
Protein Families	Druggable Genome
Protein Pathways	Metabolic pathways, Tryptophan metabolism

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