VMAT2 (SLC18A2) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC, WB
Recommend Dilution	WB: 500-2000 WB positive control: Human cervical cancer tissue IHC: 25-100 Positive control: Human brain Predicted cell location: Cytoplasm
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic peptide corresponding to a region derived from 500-514 amino acids of human solute carrier family 18 (vesicular monoamine), member 2
Formulation	PBS pH7.3, 0.05% NaN3, 50% glycerol
Concentration	lot specific
Purification	Antigen affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	55 kDa
Gene Name	solute carrier family 18 member A2
Database Link	NP_003045 Entrez Gene 25549 RatEntrez Gene 214084 MouseEntrez Gene 6571 Human UniProt ID Q05940
Background	The vesicular monoamine transporter acts to accumulate cytosolic monoamines into synaptic vesicles; using the proton gradient maintained across the synaptic vesicular membrane. Its proper function is essential to the correct activity of the monoaminergic systems that have been implicated in several human neuropsychiatric disorders. The transporter is a site of action of important drugs; including reserpine and tetrabenazine .
Synonyms	SVAT; SVMT; VAT2; VMAT2
Reference Data
Protein Families	Transmembrane
Protein Pathways	Parkinson's disease

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