Paxillin (PXN) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC, WB
Recommend Dilution	WB: 200-1000 WB positive control: HT-29 cell lysate IHC: 30-150 Positive control: Human ovarian cancer Predicted cell location: Cytoplasm
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic peptide corresponding to a region derived from 1-15 amino acids of Human paxillin
Formulation	PBS pH7.3, 0.05% NaN3, 50% glycerol
Concentration	lot specific
Purification	Antigen affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	66 kDa
Gene Name	paxillin
Database Link	NP_002850 Entrez Gene 19303 MouseEntrez Gene 360820 RatEntrez Gene 5829 Human UniProt ID P49023
Background	This gene encodes a cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion). Alternatively spliced transcript variants encoding different isoforms have been described for this gene. These isoforms exhibit different expression pattern; and have different biochemical; as well as physiological properties (PMID:9054445).
Synonyms	FLJ16691
Reference Data
Protein Families	Druggable Genome, Stem cell - Pluripotency
Protein Pathways	Chemokine signaling pathway, Focal adhesion, Leukocyte transendothelial migration, Regulation of actin cytoskeleton, VEGF signaling pathway

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