gamma Catenin (JUP) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC, WB
Recommend Dilution	WB: 200-1000 WB positive control: A549 and human fetal brain tissue IHC: 25-100 Positive control: Human cervical cancer Predicted cell location: Cell membrane
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic peptide corresponding to a region derived from 708-722 amino acids of Human junction plakoglobin
Formulation	PBS pH7.3, 0.05% NaN3, 50% glycerol
Concentration	lot specific
Purification	Antigen affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	82 kDa
Gene Name	junction plakoglobin
Database Link	NP_002221 Entrez Gene 16480 MouseEntrez Gene 81679 RatEntrez Gene 3728 Human UniProt ID P14923
Background	This gene encodes a major cytoplasmic protein which is the only known constituent common to submembranous plaques of both desmosomes and intermediate junctions. This protein forms distinct complexes with cadherins and desmosomal cadherins and is a member of the catenin family since it contains a distinct repeating amino acid motif called the armadillo repeat. Mutation in this gene has been associated with Naxos disease. Alternative splicing occurs in this gene; however; not all transcripts have been fully described.
Synonyms	ARVD12; CTNNG; DP3; DPIII; PDGB; PKGB
Reference Data
Protein Families	Druggable Genome
Protein Pathways	Acute myeloid leukemia, Arrhythmogenic right ventricular cardiomyopathy (ARVC), Pathways in cancer

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