Aconitase 1 (ACO1) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC
Recommend Dilution	IHC: 50-200 Positive control: Human liver cancer Predicted cell location: Cytoplasm
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic peptide corresponding to a region derived from 132-146 amino acids of human aconitase 1, soluble
Formulation	PBS pH7.3, 0.05% NaN3, 50% glycerol
Concentration	lot specific
Purification	Antigen affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	aconitase 1
Database Link	NP_002188 Entrez Gene 11428 MouseEntrez Gene 50655 RatEntrez Gene 48 Human UniProt ID P21399
Background	Aconitase 1; also known as iron regulatory element binding protein 1 (IREB1); is a cytosolic protein which binds to iron-responsive elements (IREs). IREs are stem-loop structures found in the 5' UTR of ferritin mRNA; and in the 3' UTR of transferrin receptor mRNA. The iron-induced binding to the IRE results in repression of translation of ferritin mRNA; and inhibition of degradation of the otherwise rapidly degrading transferrin receptor mRNA. Thus; IREB1 plays a central role in cellular iron homeostasis. It was also shown to have aconitase activity; and hence grouped with the aconitase family of enzymes.
Synonyms	ACONS; HEL60; IREB1; IREBP; IREBP1; IRP1
Reference Data
Protein Families	Druggable Genome
Protein Pathways	Citrate cycle (TCA cycle), Glyoxylate and dicarboxylate metabolism, Metabolic pathways

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