DUT Rabbit Polyclonal Antibody

CAT#: TA321412S

Anti-DUT Rabbit Polyclonal Antibody

Size: 25 ul 100 ul



Need it in bulk or conjugated?
Get a free quote

CNY 800.00

CNY 1,280.00


货期*
2周

规格
    • 25 ul

Product images

经常一起买 (3)
beta Actin Mouse Monoclonal Antibody, Clone OTI1, Loading Control
    • 30 ul

CNY 300.00
CNY 1,430.00


Purified recombinant protein of Homo sapiens deoxyuridine triphosphatase (DUT), nuclear gene encoding mitochondrial protein, transcript variant 3, 20 µg
    • 20 ug

CNY 2,900.00
CNY 6,650.00


Transient overexpression lysate of deoxyuridine triphosphatase (DUT), nuclear gene encoding mitochondrial protein, transcript variant 2
    • 100 ug

CNY 3,080.00

Specifications

Product Data
Applications IHC
Recommend Dilution IHC: 25-100
Positive control: Human gasrtic cancer
Predicted cell location: Cytoplasm and Nucleus
Reactivity Human, Rat
Host Rabbit
Clonality Polyclonal
Immunogen Synthetic peptide corresponding to a region derived from 132-244 amino acids of Human Deoxyuridine triphosphatase
Formulation PBS pH7.3, 0.05% NaN3, 50% glycerol
Purification Antigen affinity purification
Conjugation Unconjugated
Storage Condition Store at -20°C as received.
Predicted Protein Size 27 kDa
Gene Name deoxyuridine triphosphatase
Background This gene encodes an essential enzyme of nucleotide metabolism. The encoded protein forms a ubiquitous; homotetrameric enzyme that hydrolyzes dUTP to dUMP and pyrophosphate. This reaction serves two cellular purposes: providing a precursor (dUMP) for the synthesis of thymine nucleotides needed for DNA replication; and limiting intracellular pools of dUTP. Elevated levels of dUTP lead to increased incorporation of uracil into DNA; which induces extensive excision repair mediated by uracil glycosylase. This repair process; resulting in the removal and reincorporation of dUTP; is self-defeating and leads to DNA fragmentation and cell death. Alternative splicing of this gene leads to different isoforms that localize to either the mitochondrion or nucleus. A related pseudogene is located on chromosome 19.
Synonyms dUTPase
Reference Data
Protein Families Druggable Genome
Protein Pathways Metabolic pathways, Pyrimidine metabolism
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
Customer Reviews 
Loading...