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DUT Rabbit Polyclonal Antibody
CAT＃: TA321412S
Anti-DUT Rabbit Polyclonal Antibody
Size: 100 ul
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CNY 800.00
CNY 1,280.00
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CNY 300.00
CNY 1,430.00
CNY 2,900.00
CNY 6,650.00
CNY 3,080.00
Specifications
| Product Data | |
| Applications | IHC |
| Recommend Dilution | IHC: 25-100 Positive control: Human gasrtic cancer Predicted cell location: Cytoplasm and Nucleus |
| Reactivity | Human, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Immunogen | Synthetic peptide corresponding to a region derived from 132-244 amino acids of Human Deoxyuridine triphosphatase |
| Formulation | PBS pH7.3, 0.05% NaN3, 50% glycerol |
| Purification | Antigen affinity purification |
| Conjugation | Unconjugated |
| Storage Condition | Store at -20°C as received. |
| Predicted Protein Size | 27 kDa |
| Gene Name | deoxyuridine triphosphatase |
| Database Link | |
| Background | This gene encodes an essential enzyme of nucleotide metabolism. The encoded protein forms a ubiquitous; homotetrameric enzyme that hydrolyzes dUTP to dUMP and pyrophosphate. This reaction serves two cellular purposes: providing a precursor (dUMP) for the synthesis of thymine nucleotides needed for DNA replication; and limiting intracellular pools of dUTP. Elevated levels of dUTP lead to increased incorporation of uracil into DNA; which induces extensive excision repair mediated by uracil glycosylase. This repair process; resulting in the removal and reincorporation of dUTP; is self-defeating and leads to DNA fragmentation and cell death. Alternative splicing of this gene leads to different isoforms that localize to either the mitochondrion or nucleus. A related pseudogene is located on chromosome 19. |
| Synonyms | dUTPase |
| Reference Data | |
| Protein Families | Druggable Genome |
| Protein Pathways | Metabolic pathways, Pyrimidine metabolism |
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