CDC42 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	WB: 200-1000 WB positive control: Human fetal brain tissue
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic peptide corresponding to a region derived from 57-71 amino acids of Human Cell division cycle 42
Formulation	PBS pH7.3, 0.05% NaN3, 50% glycerol
Concentration	lot specific
Purification	Antigen affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	23 kDa
Gene Name	cell division cycle 42
Database Link	NP_001782 Entrez Gene 12540 MouseEntrez Gene 64465 RatEntrez Gene 998 Human UniProt ID P60953
Background	The protein encoded by this gene is a small GTPase of the Rho-subfamily; which regulates signaling pathways that control diverse cellular functions including cell morphology; migration; endocytosis and cell cycle progression. This protein is highly similar to Saccharomyces cerevisiae Cdc 42; and is able to complement the yeast cdc42-1 mutant. The product of oncogene Dbl was reported to specifically catalyze the dissociation of GDP from this protein. This protein could regulate actin polymerization through its direct binding to Neural Wiskott-Aldrich syndrome protein (N-WASP); which subsequently activates Arp2/3 complex. Alternative splicing of this gene results in multiple transcript variants.
Synonyms	CDC42Hs; G25K
Reference Data
Protein Families	Druggable Genome
Protein Pathways	Adherens junction, Axon guidance, Chemokine signaling pathway, Endocytosis, Epithelial cell signaling in Helicobacter pylori infection, Fc gamma R-mediated phagocytosis, Focal adhesion, GnRH signaling pathway, Leukocyte transendothelial migration, MAPK signaling pathway, Neurotrophin signaling pathway, Pancreatic cancer, Pathogenic Escherichia coli infection, Pathways in cancer, Regulation of actin cytoskeleton, Renal cell carcinoma, T cell receptor signaling pathway, Tight junction, VEGF signaling pathway

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