ABH2 (ALKBH2) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	WB: 500-2000 WB positive control: Human fetal liver and seminoma tissue, RAW264.7 cells
Reactivity	Human, Mouse
Host	Rabbit
Clonality	Polyclonal
Immunogen	Full length fusion protein
Formulation	PBS pH7.3, 0.05% NaN3, 50% glycerol
Concentration	lot specific
Purification	Antigen affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	29 kDa
Gene Name	alkB homolog 2, alpha-ketoglutarate-dependent dioxygenase
Database Link	NP_001001655 Entrez Gene 231642 MouseEntrez Gene 121642 Human UniProt ID Q6NS38
Background	The Escherichia coli AlkB protein protects against the cytotoxicity of methylating agents by repair of the specific DNA lesions generated in single-stranded DNA. ALKBH2 and ALKBH3 are E. coli AlkB homologs that catalyze the removal of 1-methyladenine and 3-methylcytosine. Dioxygenase that repairs alkylated DNA and RNA containing 1-methyladenine and 3-methylcytosine by oxidative demethylation. Can also repair alkylated DNA containing 1-ethenoadenine (in vitro). Has strong preference for double-stranded DNA. Has low efficiency with single-stranded substrates. Requires molecular oxygen; alpha-ketoglutarate and iron.
Synonyms	ABH2
Reference Data
Protein Families	Druggable Genome

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