PTGS1 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC
Recommend Dilution	IHC: 20-100 Positive control: Human stomach cancer Predicted cell location: Cytoplasm
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic peptide corresponding to a region derived from 586-599 amino acids of Human prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
Formulation	PBS pH7.3, 0.05% NaN3, 50% glycerol
Concentration	lot specific
Purification	Antigen affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	prostaglandin-endoperoxide synthase 1
Database Link	NP_542158 Entrez Gene 5742 Human UniProt ID P23219
Background	Cyclooxygenase-1 (COX-1); also known as prostaglandin G/H synthase 1; prostaglandin-endoperoxide synthase 1 or prostaglandin H2 synthase 1; is an enzyme that in humans is encoded by the PTGS1 gene. This is one of two genes encoding similar enzymes that catalyze the conversion of arachinodate to prostaglandin. The encoded protein regulates angiogenesis in endothelial cells; and is inhibited by nonsteroidal anti-inflammatory drugs such as aspirin. The protein may promote cell proliferation during tumor progression. Alternative splicing results in multiple transcript variants.
Synonyms	COX1; COX3; HS; PCOX1; PES-1; PGG; PGHS-1; PGHS1; PHS1; PTGHS
Reference Data
Protein Families	Druggable Genome, Transmembrane
Protein Pathways	Arachidonic acid metabolism, Metabolic pathways

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