Amylin (IAPP) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	WB: 200-1000 WB positive control: Raji cells
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic peptide corresponding to a region derived from 40-52 amino acids of Human Islet amyloid polypeptide
Formulation	PBS pH7.3, 0.05% NaN3, 50% glycerol
Concentration	lot specific
Purification	Antigen affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	10 kDa
Gene Name	islet amyloid polypeptide
Database Link	NP_000406 Entrez Gene 15874 MouseEntrez Gene 24476 RatEntrez Gene 3375 Human UniProt ID P10997
Background	Islet; or insulinoma; amyloid polypeptide is commonly found in pancreatic islets of patients suffering diabetes mellitus type II; or harboring an insulinoma. While the association of amylin with the development of type II diabetes has been known for some time; a direct causative role for amylin has been harder to establish. Studies suggest that amylin; like the related beta-amyloid (Abeta) associated with Alzheimer's disease; can induce apoptotic cell-death in particular cultured cells; an effect that may be relevant to the development of type II diabetes.
Synonyms	DAP; IAP
Reference Data
Protein Families	Druggable Genome, Secreted Protein
Protein Pathways	Maturity onset diabetes of the young

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