PDX1 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC, WB
Recommend Dilution	WB: 200-1000 WB positive control: Hela and Jurkat cells IHC: 15-50 Positive control: Human gasrtic cancer Predicted cell location: Cytoplasm
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic peptide peptide corresponding to a region derived from 18-31 amino acids of human pancreatic and duodenal homeobox 1
Formulation	PBS pH7.3, 0.05% NaN3, 50% glycerol
Concentration	lot specific
Purification	Antigen affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	31 kDa
Gene Name	pancreatic and duodenal homeobox 1
Database Link	NP_000200 Entrez Gene 18609 MouseEntrez Gene 29535 RatEntrez Gene 3651 Human UniProt ID P52945
Background	The protein encoded by this gene is a transcriptional activator of several genes; including insulin; somatostatin; glucokinase; islet amyloid polypeptide; and glucose transporter type 2. The encoded nuclear protein is involved in the early development of the pancreas and plays a major role in glucose-dependent regulation of insulin gene expression. Defects in this gene are a cause of pancreatic agenesis; which can lead to early-onset insulin-dependent diabetes mellitus (NIDDM); as well as maturity onset diabetes of the young type 4 (MODY4).
Synonyms	GSF; IDX-1; IPF1; IUF1; MODY4; PAGEN1; PDX-1; STF-1
Reference Data
Protein Families	Embryonic stem cells, ES Cell Differentiation/IPS, Induced pluripotent stem cells, Transcription Factors
Protein Pathways	Maturity onset diabetes of the young, Type II diabetes mellitus

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