Glucokinase (GCK) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC
Recommend Dilution	IHC: 25-100 Positive control: Human colon cancer Predicted cell location: Cytoplasm
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic peptide corresponding to a region derived from 3-17 amino acids of Human glucokinase (hexokinase 4)
Formulation	PBS pH7.3, 0.05% NaN3, 50% glycerol
Concentration	lot specific
Purification	Antigen affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	glucokinase
Database Link	NP_000153 Entrez Gene 24385 RatEntrez Gene 103988 MouseEntrez Gene 2645 Human UniProt ID P35557
Background	Hexokinases phosphorylate glucose to produce glucose-6-phosphate; the first step in most glucose metabolism pathways. Alternative splicing of this gene results in three tissue-specific forms of glucokinase; one found in pancreatic islet beta cells and two found in liver. The protein localizes to the outer membrane of mitochondria. In contrast to other forms of hexokinase; this enzyme is not inhibited by its product glucose-6-phosphate but remains active while glucose is abundant. Mutations in this gene have been associated with non-insulin dependent diabetes mellitus (NIDDM); maturity onset diabetes of the young; type 2 (MODY2) and persistent hyperinsulinemic hypoglycemia of infancy (PHHI).
Synonyms	FGQTL3; GK; GLK; HHF3; HK4; HKIV; HXKP; LGLK; MODY2
Reference Data
Protein Families	Druggable Genome
Protein Pathways	Amino sugar and nucleotide sugar metabolism, Galactose metabolism, Glycolysis / Gluconeogenesis, Insulin signaling pathway, Maturity onset diabetes of the young, Metabolic pathways, Starch and sucrose metabolism, Type II diabetes mellitus

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