Angiotensinogen (AGT) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	WB: 500-2000 WB positive control: Human liver cancer tissue
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic peptide peptide corresponding to a region derived from 34-41 amino acids of human angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
Formulation	PBS pH7.3, 0.05% NaN3, 50% glycerol
Concentration	lot specific
Purification	Antigen affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	53 kDa
Gene Name	angiotensinogen
Database Link	NP_000020 Entrez Gene 183 Human UniProt ID P01019
Background	The protein encoded by this gene; pre-angiotensinogen or angiotensinogen precursor; is expressed in the liver and is cleaved by the enzyme renin in response to lowered blood pressure. The resulting product; angiotensin I; is then cleaved by angiotensin converting enzyme (ACE) to generate the physiologically active enzyme angiotensin II. The protein is involved in maintaining blood pressure and in the pathogenesis of essential hypertension and preeclampsia. Mutations in this gene are associated with susceptibility to essential hypertension; and can cause renal tubular dysgenesis; a severe disorder of renal tubular development. Defects in this gene have also been associated with non-familial structural atrial fibrillation; and inflammatory bowel disease.
Synonyms	ANHU; SERPINA8
Reference Data
Protein Families	Druggable Genome, Secreted Protein
Protein Pathways	Renin-angiotensin system

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