CD11b (ITGAM) Mouse Monoclonal Antibody [Clone ID: CBRM1/5]

Specifications

Product Data
Clone Name	CBRM1/5
Recommend Dilution	Flow, Functional Assay, IP
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Formulation	Aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Concentration	lot specific
Purification	Affinity purified
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	integrin subunit alpha M
Database Link	NP_000623 Entrez Gene 3684 Human UniProt ID P11215
Background	The CBRM1/5 monoclonal antibody reacts with an activation-specific epitope of human Mac-1. CBRM1/5 binds a subset of Mac-1 molecules on neutrophils and monocytes after stimulation with chemoattractants or phorbol esters but does not recognize Mac-1 on resting myeloid cells. Through interactions with its ligands, Mac-1 participates in adhesive cell interactions. The epitope recognized by this mAb localizes to the I domain on the α chain of Mac-1 very close to the ligand binding site in a region that is widely exposed. CBRM1/5 blocks Mac-1 dependent adhesion to fibrinogen and ICAM-1 and inhibits chemoattractant-stimulated adhesion of eosinophils to the Intercellular Adhesion Molecule-1 (ICAM-1). It should be noted that low level activation may occur during processing of freshly drawn blood. Therefore the CBRM1.5 antibody may exhibit some binding to Mac-1 in these unstimulated samples. However, higher levels of Mac-1 expression are observed in activated samples when compared to unstimulated cells.
Synonyms	CD11B; CR3A; MAC-1; MAC1A; MO1A; SLEB6
Reference Data
Protein Families	Druggable Genome, ES Cell Differentiation/IPS, Transmembrane
Protein Pathways	Cell adhesion molecules (CAMs), Hematopoietic cell lineage, Leukocyte transendothelial migration, Regulation of actin cytoskeleton

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