CCR7 Rat Monoclonal Antibody [Clone ID: 3D12]
CAT#: TA320232
Rat Anti-Human CD197 (CCR7) Purified (100 ug)
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CNY 2,650.00
Cited in 1 publication. |
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CNY 300.00
CNY 1,430.00
CNY 2,900.00
CNY 6,650.00
Specifications
Product Data | |
Clone Name | 3D12 |
Recommend Dilution | Flow, IHC |
Reactivity | Human |
Host | Rat |
Clonality | Monoclonal |
Formulation | Aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer |
Concentration | lot specific |
Purification | Affinity purified |
Conjugation | Unconjugated |
Storage Condition | Store at -20°C as received. |
Gene Name | C-C motif chemokine receptor 7 |
Database Link | |
Background | The 3D12 monoclonal antibody reacts with human CCR7, also known as EBI-1 and CD197. CCR7 is a member of the G-protein-coupled chemokine receptor family with seven membrane-spanning domains and functions as a receptor for 6Ckine/SLC (secondary lymphoid-tissue chemokine), CCL19 and CCL21. CCR7 has been shown to be internalized via clathrin-coated pits and the majority recycled back to the plasma membrane. CCR7 is expressed on T cells and can be used to distinguish populations of na?ve from central and effector memory T cells. CCR7 has been shown to play a role in migration of memory T cells to inflamed tissue. Expression of CCR7 is also found on DC??. During DC maturation CCR7 expression increases and is thought to be involved in a variety of functions: chemotaxis to the lymph node, cellular architecture, rate of endocytosis, survival and maturation. Expression of CCR7 on the cell surface can be down regulated upon ligand binding. |
Synonyms | BLR2; CD197; CDw197; CMKBR7; EBI1 |
Reference Data | |
Protein Families | Druggable Genome, GPCR, Transmembrane |
Protein Pathways | Chemokine signaling pathway, Cytokine-cytokine receptor interaction |
Citations (1)
The use of this Antibodies has been cited in the following citations: |
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Non-Genetic Reprogramming of Monocytes via Microparticle Phagocytosis for Sustained Modulation of Macrophage Phenotype
,Wofford, KL;Singh, BS;Cullen, DK;Spiller, KL;,
bioRxiv
[CCR7]
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