SHISA3 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IF, IHC, WB
Recommend Dilution	WB: 1 ug/mL
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	SHISA3 antibody was raised against a 15 amino acid peptide near the center of human SHISA3 .
Formulation	SHISA3 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration	1ug/ul
Purification	SHISA3 Antibody is affinity chromatography purified via peptide column.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	Predicted: 26 kDa; Observed: 28 kDa
Gene Name	shisa family member 3
Database Link	NP_001073974 Entrez Gene 330096 MouseEntrez Gene 498356 RatEntrez Gene 152573 Human UniProt ID A0PJX4
Background	SHISA3 Antibody: SHISA3 plays an essential role in the maturation of presomitic mesoderm cells by individual attenuation of both FGF and WNT signaling. The Shisa family of single-transmembrane proteins is characterized by an N-terminal cysteine-rich domain and a proline-rich C-terminal region. Its founding member, Xenopus Shisa, promotes head development by antagonizing Wnt and FGF signaling. Shisa physically interacted with immature forms of the Wnt receptor Frizzled and the FGF receptor within the ER and inhibited their posttranslational maturation and trafficking to the cell surface. Loss of Shisa function sensitized the neuroectoderm to Wnt signaling and suppressed head formation during gastrulation.
Synonyms	hShisa3
Reference Data
Protein Families	Transmembrane

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