SCUBE1 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IF, WB
Recommend Dilution	WB: 1 ug/mL, ICC: 20 ug/mL, IF: 20 ug/mL
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	SCUBE1 antibody was raised against a 14 amino acid synthetic peptide near the center of human SCUBE1.
Formulation	SCUBE1 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration	1ug/ul
Purification	SCUBE1 Antibody is affinity chromatography purified via peptide column.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	signal peptide, CUB domain and EGF like domain containing 1
Database Link	NP_766638 Entrez Gene 80274 Human UniProt ID Q8IWY4
Background	SCUBE1 Antibody: SCUBE1 is an EGF-related protein with a CUB (C1s-like) domain that is expressed primarily in the developing gonad, nervous system, somites, surface ectoderm and limb buds. The N-terminal EGF-like repeats of SCUBE1 participate in the formation of adhesions in a Ca2+-dependent fashion. In contrast, the C-terminal cysteine-rich motifs and CUB domain can directly bind and antagonize bone morphogenic protein activity; genetic ablation of this region resulted in brain malformation in mice embryos, suggesting SCUBE1 plays a role in brain morphogenesis. SCUBE1 has also been implicated in early craniofacial development in mice.
Synonyms	SCUBE1
Reference Data
Protein Families	Druggable Genome, Secreted Protein

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