CARD14 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC
Recommend Dilution	IHC: 5 ug/mL
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	CARMA2 antibody was raised against a 14 amino acid synthetic peptide near the carboxy terminus of human CARMA2.
Formulation	CARMA2 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration	1ug/ul
Purification	CARMA2 Antibody is affinity chromatography purified via peptide column.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	caspase recruitment domain family member 14
Database Link	NP_077015 Entrez Gene 79092 Human UniProt ID Q9BXL6
Background	CARMA2 Antibody: CARMA proteins belong to the membrane-associated guan-ylate kinase-like (MAGUK) family of proteins that can function as molecular scaffolds that assist assembly of signal transduction molecules. CARMA1, CARMA2, and CARMA3 share high degrees of sequence and functional homology, but their tissue-specific distribution suggests that they serve distinct biological functions in different cell types. As with CARMA1, the CARD domain of CARMA2 has been shown to specifically interact with BCL10, a protein known to function as a positive regulator of cell apoptosis and NF-κB activation. When expressed in cells, this protein activated NF-κB and induced the phosphorylation of BCL10 Alternative splicing of CARMA2 results in isoforms that possess differential effects on NF-κB activation and endoplasmic reticulum stress-induced cell death.
Synonyms	BIMP2; CARMA2; PRP; PSORS2; PSS1
Reference Data

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