PTCHD2 (DISP3) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC
Recommend Dilution	IHC: 5 ug/mL
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	PTCHD2 antibody was raised against a 19 amino acid synthetic peptide from near the amino terminus of human PTCHD2.
Formulation	PTCHD2 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration	1ug/ul
Purification	PTCHD2 Antibody is affinity chromatography purified via peptide column.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	dispatched RND transporter family member 3
Database Link	NP_065831 Entrez Gene 57540 Human UniProt ID Q9P2K9
Background	PTCHD2 Antibody: PTCHD2, also known as DISP3, is the third of three known homologs of the D. melanogaster protein Dispatched. It is a multi-transmembrane protein containing two PTCH/DISP domains and is thought to be involved in the release of lipid-anchored secreted proteins. Like DISP1 and DISP2, DISP3 has been implicated in signaling pathways during embryogenesis, tissue regeneration, and carcinogenesis. It is highly expressed in Purkinje cells, hippocampal neurons, and retinal ganglion cells. Recently, it has been shown that PTCHD2 localizes within the endoplasmic reticulum and colocalizes with cholesterol, and given that its expression is regulated by thyroid hormone (T3), it has been suggested that DISP3 may be a link between thyroid hormone and cholesterol metabolism.
Synonyms	PTCHD2
Reference Data
Protein Families	Transmembrane

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