NCLN Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IF, IHC, WB
Recommend Dilution	WB: 0.5 ug/mL, ICC: 2.5 ug/mL
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	NCLN antibody was raised against an 18 amino acid synthetic peptide near the carboxy terminus of human NCLN.
Formulation	NCLN Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration	1 mg/ml
Purification	NCLN Antibody is affinity chromatography purified via peptide column.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	nicalin
Database Link	NP_064555 Entrez Gene 103425 MouseEntrez Gene 314648 RatEntrez Gene 56926 Human UniProt ID Q969V3
Background	NCLN Antibody: Nicalin, along with its binding partner Nomo, is a novel signaling antagonist to Nodals, signaling factors of the TGF-β superfamily that play a key role in vertebrate development. Nicalin is distantly related to Nicastrin, a component of the Alzheimer's disease-associated gamma-secretase, and is thought to have a similar function. Another protein, TMEM147, has also been recently identified as associating with Nicalin and NOMO as part of the gamma-secretase-like complex.
Synonyms	NET59
Reference Data
Protein Families	Transmembrane

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