KCNK12 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IF, IHC, WB
Recommend Dilution	WB: 0.5 ug/mL, ICC: 5 ug/mL, IF: 20 ug/mL
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	KCNK12 antibody was raised against a 14 amino acid synthetic peptide near the carboxy terminus of human KCNK12.
Formulation	KCNK12 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration	1ug/ul
Purification	KCNK12 Antibody is affinity chromatography purified via peptide column.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	potassium two pore domain channel subfamily K member 12
Database Link	NP_071338 Entrez Gene 64119 RatEntrez Gene 210741 MouseEntrez Gene 56660 Human UniProt ID Q9HB15
Background	KCNK12 Antibody: KCNK13 and KCNK12 (also known as THIK1 and 2) are the first two members of a novel two pore-forming P domains K+ channels subfamily. The pore loop domain, a highly conserved region common to all potassium channels, is involved in determining potassium ion selectivity. Members of this family are all characterized by four transmembrane domains and may function to help influence the resting membrane potential of cells. KCNK12 is expressed mainly in the brain and lung, but also observed in the kidneys, heart and skeletal muscle. KCNK12 is closely related to KCNK13 (58% identity at the amino acid level), but could not yet been functionally expressed in vitro and may require other proteins to become active.
Synonyms	K2p12.1; THIK-2; THIK2
Reference Data
Protein Families	Druggable Genome, Ion Channels: Potassium, Transmembrane

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