WAC Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IF, IHC, WB
Recommend Dilution	WB: 1 ug/mL
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	WAC antibody was raised against a 19 amino acid peptide near the center of human WAC .
Formulation	WAC Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration	1ug/ul
Purification	WAC Antibody is affinity chromatography purified via peptide column.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	Predicted: 71 kDa; Observed: 75 kDa
Gene Name	WW domain containing adaptor with coiled-coil
Database Link	NP_057712 Entrez Gene 225131 MouseEntrez Gene 307029 RatEntrez Gene 51322 Human UniProt ID Q9BTA9
Background	WAC Antibody: The WW domain containing adaptor with coiled-coil protein (WAC) contains a WW domain that mediates protein-protein interactions and colocalizes with RNA splicing factor SC35. Further studies have indicated that WAC is a functional partner of the RNF20/40 complex that ubiquitinates Histone H2B, and that WAC regulates H2B ubiquitination. WAC targets RNF20/40 to associate with RNA polymerase II complex for H2B ubiquitination at active transcription sites. WAC-dependent transcription is also important for cell-cycle checkpoint activation in response to genotoxic stress.
Synonyms	BM-016; DESSH; PRO1741; Wwp4
Reference Data

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