MECR Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	WB: 1 - 2 ug/mL
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Rabbit polyclonal MECR antibody was raised against a 15 amino acid peptide near the carboxy terminus of human MECR.
Formulation	MECR Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration	1ug/ul
Purification	MECR Antibody is affinity chromatography purified via peptide column.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	41 kDa
Gene Name	mitochondrial trans-2-enoyl-CoA reductase
Database Link	NP_057095 Entrez Gene 26922 MouseEntrez Gene 29470 RatEntrez Gene 51102 Human UniProt ID Q9BV79
Background	MECR Antibody: The mitochondrial trans-2-enoyl-CoA reductase (MECR), was initially identified as nuclear receptor-binding factor 1 (NRBF1), which can interact with a multitude of nuclear hormone receptors in the presence of the respective ligands. MECR has been shown to be part of the mitochondrial fatty acid synthesis (FAS II) system and to catalyze the NAPDH-dependent reduction of 2-enoyl thioesters, generating saturated acyl-groups. Overexpression of this gene in transgenic mice can lead to cardiac abnormalities, suggesting that inappropriate expression of genes of FAS II can result in the development of hereditary cardiomyopathy.
Synonyms	CGI-63; FASN2B; NRBF1
Reference Data
Protein Families	Druggable Genome
Protein Pathways	Fatty acid elongation in mitochondria, Metabolic pathways

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