DC SIGN (CD209) Mouse Monoclonal Antibody [Clone ID: 5D7]
CNY 6,653.00
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CNY 300.00
CNY 1,430.00
CNY 3,080.00
Specifications
Product Data | |
Clone Name | 5D7 |
Applications | ELISA, IHC, WB |
Recommend Dilution | DC-SIGN antibody can be used for detection of DC-SIGN in Western Blot at 1 µg/mL and in immunohistochemistry at 5 - 10 µg/mL. Antibody validated: Western Blot in human samples and Immunohistochemistry in human samples. All other applications and species not yet tested. |
Reactivity | Human |
Host | Mouse |
Clonality | Monoclonal |
Immunogen | A recombinant His-tagged protein fragment corresponding to the extracellular region of human DC-SIGN. |
Formulation | DC-SIGN Monoclonal Antibody is supplied in PBS containing 0.02% sodium azide. |
Concentration | 1ug/ul |
Purification | DC-SIGN Monoclonal Antibody is Protein A purified. |
Conjugation | Unconjugated |
Storage Condition | Store at -20°C as received. |
Gene Name | CD209 molecule |
Database Link | |
Background | DC-SIGN Monoclonal Antibody: Dendritic cells (DCs) that control immune responses were recently found to capture and transport HIV from the mucosal area to remote lymph nodes, where DCs hand over HIV to CD4+ T lymphocytes. DCs also amplify the amount of virus and extend the duration of viral infectivity. Multiple strains of HIV-1, HIV-2 and SIV bind to DCs via DC-SIGN. ICAM-3 is the natural ligand for DC-SIGN. A DC-SIGN homologue (termed DC-SIGNR, L-SIGN, and DC-SIGN2) was identified recently. DC-SIGN forms a novel gene family with DC-SIGNR and many alternatively spliced isoforms of DC-SIGN and DC-SIGNR. The expression of DC-SIGN was found in mucosal tissues including placenta, small intestine, and rectum. |
Synonyms | CDSIGN; CLEC4L; DC-SIGN; DC-SIGN1 |
Reference Data | |
Protein Families | Druggable Genome |
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