GPR44 (PTGDR2) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IF, WB
Recommend Dilution	WB: 0.5 - 1 ug/mL
Reactivity	Human, Mouse
Host	Rabbit
Clonality	Polyclonal
Immunogen	Rabbit polyclonal PTGDR2 antibody was raised against a 19 amino acid peptide near the center of human PTGDR2.
Formulation	PTGDR2 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration	1ug/ul
Purification	PTGDR2 Antibody is affinity chromatography purified via peptide column.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	43 kDa
Gene Name	prostaglandin D2 receptor 2
Database Link	NP_004769 Entrez Gene 14764 MouseEntrez Gene 11251 Human UniProt ID Q9Y5Y4
Background	PTGDR2 Antibody: The prostaglandin D2 receptor 2 (PTGDR2), also known as CRTH2, is expressed on Th2 cells and eosinophils and mediates chemotaxis of these cells to PGD2 and is thus thought to be a key receptor mediating eosinophil and Th2 recruitment during allergic responses. However, PTGDR2-null mice showed enhanced eosinophil recruitment into the lung consistent with observations that the PTGDR2-null mice produced significantly higher amounts of interleukin-5 (IL-5) and IL-3. This suggests that PTGDR2 plays a nonredundant role in restricting eosinophilia and allergic response in vivo.
Synonyms	CD294; CRTH2; DL1R; DP2; GPR44
Reference Data
Protein Families	Druggable Genome, GPCR, Transmembrane

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