SIVA (SIVA1) Chicken Polyclonal Antibody
CNY 5,808.00
CNY 300.00
CNY 1,430.00
CNY 9,998.00
CNY 3,080.00
Specifications
Product Data | |
Applications | IF, WB |
Recommend Dilution | WB: 1 ug/mL, IF: 20 ug/mL |
Reactivity | Human, Mouse |
Host | Chicken |
Clonality | Polyclonal |
Immunogen | SIVA antibody was raised against a 16 amino acid synthetic peptide near the amino terminus of human SIVA. |
Formulation | SIVA Antibody is supplied in PBS containing 0.02% sodium azide. |
Concentration | 1ug/ul |
Purification | SIVA Antibody is affinity chromatography purified via peptide column. |
Conjugation | Unconjugated |
Storage Condition | Store at -20°C as received. |
Gene Name | SIVA1 apoptosis inducing factor |
Database Link | |
Background | SIVA Antibody: SIVA plays an important role in the apoptotic pathway induced by the CD27 antigen, a member of the tumor necrosis factor receptor (TFNR) superfamily. SIVA is a small cysteine-rich protein with a unique N-terminal amphipathic helical region, a death domain homology region (DDHR) and a C-terminal cysteine-rich B-box-like or zinc-finger-like structure. The DDHR domain binds to CD27 and induces apoptosis in T cells through a caspase-dependent mitochondrial pathway. SIVA inhibits BCL2L1 isoform Bcl-xL anti-apoptotic activity and inhibits activation of NFκ-B and promotes T-cell receptor-mediated apoptosis. SIVA represents a potential therapeutic target for the treatment of neuronal cell death diseases. |
Synonyms | CD27BP; SIVA; Siva-1; Siva-2 |
Reference Data |
Documents
Product Manuals |
FAQs |
SDS |
Resources
抗体相关资料 |