SIVA (SIVA1) Chicken Polyclonal Antibody

CAT#: TA319827

Chicken Polyclonal SIVA Antibody



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CNY 5,808.00


货期*
5周

规格
    • 100 ug

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Specifications

Product Data
Applications IF, WB
Recommend Dilution WB: 1 ug/mL, IF: 20 ug/mL
Reactivity Human, Mouse
Host Chicken
Clonality Polyclonal
Immunogen SIVA antibody was raised against a 16 amino acid synthetic peptide near the amino terminus of human SIVA.
Formulation SIVA Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration 1ug/ul
Purification SIVA Antibody is affinity chromatography purified via peptide column.
Conjugation Unconjugated
Storage Condition Store at -20°C as received.
Gene Name SIVA1 apoptosis inducing factor
Background SIVA Antibody: SIVA plays an important role in the apoptotic pathway induced by the CD27 antigen, a member of the tumor necrosis factor receptor (TFNR) superfamily. SIVA is a small cysteine-rich protein with a unique N-terminal amphipathic helical region, a death domain homology region (DDHR) and a C-terminal cysteine-rich B-box-like or zinc-finger-like structure. The DDHR domain binds to CD27 and induces apoptosis in T cells through a caspase-dependent mitochondrial pathway. SIVA inhibits BCL2L1 isoform Bcl-xL anti-apoptotic activity and inhibits activation of NFκ-B and promotes T-cell receptor-mediated apoptosis. SIVA represents a potential therapeutic target for the treatment of neuronal cell death diseases.
Synonyms CD27BP; SIVA; Siva-1; Siva-2
Reference Data
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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