HAX1 Mouse Monoclonal Antibody [Clone ID: 9G3D11]

Specifications

Product Data
Clone Name	9G3D11
Applications	WB
Recommend Dilution	WB: 1 - 2 ug/mL
Reactivity	Human, Rat
Host	Mouse
Clonality	Monoclonal
Immunogen	Mouse monoclonal Hax1a antibody was raised against a 15 amino acid synthetic peptide near the amino terminus of human Hax1a.
Formulation	Hax1a Monoclonal Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration	1ug/ul
Purification	Hax1a Monoclonal Antibody is immunoaffinity chromotography purified IgG.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	HCLS1 associated protein X-1
Database Link	NP_006109 Entrez Gene 10456 Human UniProt ID O00165
Background	Hax1a Monoclonal Antibody: The HS-1 associated protein X-1 (Hax1) was initially identified in a yeast two-hybrid assay on the basis of its ability to bind to the hemapoietic cell-specific protein 1 (HS-1). Hax1 possesses anti-apoptotic activity and is structurally related to Bcl-2 family members, including the presence of BH1- and BH2-like domains. It has recently been shown to interact with HIV viral protein R (Vpr), a protein required for viral pathogenesis of HIV and linked to T-cell apoptosis through activation of caspases 3 and 9. Other studies indicate that Hax1-mediated processing of HtrA2 (also known as Omi) by the mitochondrial protease PARL allows survival of lymphocytes and neurons when cytokines are limiting. At least four isoforms of Hax1 are known to exist. This antibody is expected to recognize the longest isoform (Hax1a) as well as the shortest.
Synonyms	HCLSBP1; HS1BP1; SCN3
Reference Data

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