CITED2 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IF, WB
Recommend Dilution	WB: 1 - 2 ug/mL, IF: 20 ug/mL
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	CITED2 antibody was raised against an 18 amino acid synthetic peptide near the amino terminus of human CITED2.
Formulation	CITED2 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration	1ug/ul
Purification	CITED2 Antibody is affinity chromatography purified via peptide column.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	30 kDa
Gene Name	Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2
Database Link	NP_001161861 Entrez Gene 10370 Human UniProt ID Q99967
Background	CITED2 Antibody: CITED2 was initially identified as a potential transcriptional activator with significant homology to MSG1, a melanocyte-specific nuclear protein. CITED2 interacts with the histone acetyltransferase p300/CBP and acts as a coactivator to several DNA-binding transcription factors such as HIF-1 and AP-2. CITED2 also controls proliferation of mouse embryonic fibroblasts via the polycomb group genes Bmi-1 and Mel18 and the tumor suppressor Ink4a/Arf. CITED2 has also been found to be an essential regulator of adult hematopoietic stem cells (HSCs), with conditional deletion of CITED2 in the adult mouse resulting in the loss of HSCs, multilineage bone marrow failure and increased lethality.
Synonyms	ASD8; MRG-1; MRG1; P35SRJ; VSD2
Reference Data

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