TMEM59 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IF, IHC, WB
Recommend Dilution	WB: 1 ug/mL, ICC: 2.5 ug/mL, IF: 20 ug/mL
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	TMEM59 antibody was raised against a 16 amino acid synthetic peptide near amino terminus of human TMEM59.
Formulation	TMEM59 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration	1ug/ul
Purification	TMEM59 Antibody is affinity chromatography purified via peptide column.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	transmembrane protein 59
Database Link	NP_004863 Entrez Gene 9528 Human UniProt ID Q9BXS4
Background	TMEM59 Antibody: Processing of the amyloid precursor protein (APP) by two different proteases, called alpha- and beta-secretase, is a central regulatory event in the generation of the amyloid beta peptide (Abeta), which has a key role in Alzheimer disease (AD) pathogenesis. TMEM59, a Golgi-localized protein, modulates the O-glycosylation and complex N-glycosylation steps occurring during the Golgi maturation of several proteins such as APP, BACE1, SEAP or PRNP. It inhibits APP transport and shedding.
Synonyms	C1orf8; DCF1; HSPC001; PRO195; UNQ169
Reference Data
Protein Families	Transmembrane

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