Nkx2.2 (NKX2-2) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IF, IHC, WB
Recommend Dilution	WB: 1 ug/mL, ICC: 2.5 ug/mL, IF: 20 ug/mL
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	NKX2-2 antibody was raised against a 19 amino acid synthetic peptide near the center of human NKX2-2.
Formulation	NKX2-2 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration	1 mg/ml
Purification	NKX2-2 Antibody is affinity chromatography purified via peptide column.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	NK2 homeobox 2
Database Link	NP_002500 Entrez Gene 18088 MouseEntrez Gene 366214 RatEntrez Gene 4821 Human UniProt ID O95096
Background	NKX2-2 Antibody: NKX2-2 (NK2 homeobox 2) is a member of a family of transcription factors that are involved in embryonic development and cell fate. NKX2-2 is crucial in the development of pancreatic islet cell differentiation and activates the ghrelin-promoter in these cells. NKX2-2 is expressed at the onset of pancreatic epithelium formation and becomes restricted to mature α-, β- and PP cells, and in NKX2-2-null mice embryos, all β-cells and most a-cells are replaced by ghrelin-positive cells. NKX2-2 is also thought to be involved in ventral neuronal patterning and floor plate development and commissural axon guidance.
Synonyms	NKX2.2; NKX2B
Reference Data
Protein Families	Transcription Factors
Protein Pathways	Maturity onset diabetes of the young

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